منابع مشابه
Structural basis of ciliary movement.
All motile somatic cilia, including those of the human respiratory tract, are similar in ultrastructure in that they consist of an axenome of 9 + 2 microtubules surrounded by a specialized extension of the cell membrane. The axonemal elements provide the ciliary motor, which is powered by ATP hydrolysis. In respiratory cilia, mutants occur where axonemal assembly is aberrant such that the doubl...
متن کاملDistinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans.
Individual cell types can elaborate morphologically diverse cilia. Cilia are assembled via intraflagellar transport (IFT) of ciliary precursors; however, the mechanisms that generate ciliary diversity are unknown. Here, we examine IFT in the structurally distinct cilia of the ASH/ASI and the AWB chemosensory neurons in Caenorhabditis elegans, enabling us to compare IFT in specific cilia types. ...
متن کاملThe Structural Basis of Ciliary Bend Formation
The sliding microtubule model of ciliary motility predicts that cumulative local displacement (Deltal) of doublet microtubules relative to one another occurs only in bent regions of the axoneme. We have now tested this prediction by using the radial spokes which join the A subfiber of each doublet to the central sheath as markers of microtubule alignment to measure sliding displacements directl...
متن کاملSpeciation Dynamics: Generating Selective Pressure Towards Diversity
Recent approaches in evolutionary robotics (ER) propose to generate behavioral diversity in order to evolve desired behaviors more easily. These approaches require the definition of a behavioral distance which often includes task-specific features and hence a priori knowledge. Alternative methods, that do not explicitly force selective pressure towards diversity (SPTD) but still generate it, ar...
متن کاملMetabolic model for diversity-generating biosynthesis.
A conventional metabolic pathway leads to a specific product. In stark contrast, there are diversity-generating metabolic pathways that naturally produce different chemicals, sometimes of great diversity. We demonstrate that for one such pathway, tru, each ensuing metabolic step is slower, in parallel with the increasing potential chemical divergence generated as the pathway proceeds. Intermedi...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2017
ISSN: 0925-4773
DOI: 10.1016/j.mod.2017.04.145